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ea0037ep789 | Pituitary: clinical | ECE2015

Acrostart: Spanish retrospective study to determine the timeframe to achieve hormonal normalisation with initial Somatuline Autogel^® treatment in acromegaly patients in routine clinical practice

Escola Cristina Alvarez , Moreno Eva Maria Venegas , Arnes Juan Antonio Garcia , Carrera Concepcion Blanco , Azpiroz Monica Marazuela , Moreno Maria Angeles Galvez , Torre Edelmiro Menendez , Pardo Javier Aller , Vert Isabel Salinas , Resmini Eugenia , Vela Elena Maria Torres , Redondo Maria Angeles Gonzalo , Joya Ricardo Vilchez , Novoa Maria Paz de Miguel , Rabinovich Irene Halperin , Fernandez Concepcion Paramo , Alfonso Antonio Miguel Pico , Arroyo Sara , Perez Francesc , Pineda Eva

Introduction: This study aimed to determine the timeframe to achieve hormonal normalization considering dosing patterns of Somatuline Autogel (SOM, lanreotide) used in clinical practice.Methods: From March 2013 to October 2013 clinical data from 62 patients with active acromegaly treated with SOM for &gE;4 months who achieved hormonal control (GH levels <2.5 ng/ml and/or normalised IGF1 on &gE;two evaluations) at 17 Spanish hospitals were collected i...

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ea0090ep730 | Pituitary and Neuroendocrinology | ECE2023

Precision medicine in acromegaly: results of the ACROFAST study

Puig-Domingo Manel , Marques-Pamies Montserrat , Gil Joan , Valassi Elena , Gimenez-Palop Olga , Hernandez Marta , Taibo Rocio Villar , Biagetti Betina , Villarroya Gemma Xifra , Simo-Servat Andreu , Zavala Roxana , Simon Inmaculada , Araujo-Castro Marta , Centeno Rogelio Garcia , Calatayud Maria , Miguel Federico Vazquez San , Vilarrasa N , Vert Isabel Salinas , Mora Mireia , Hanzu Felicia Alexandra , Novoa Maria Paz De Miguel , Pavon Isabel , Blanco Concepcion , Alvarez-Escola Cristina , Sampedro-Nunez Miguel Antonio , Jorda Mireia , Bernabeu Ignacio , Webb Susan , Marazuela Monica

Medical treatment of acromegaly is currently performed through a trial-error manner using somatostatin receptor ligands (SRLs) as first-line drugs. Average SRLs response is seen in 50% of cases; subsequent drugs are indicated following clinical judgement. Some biomarkers either before or after surgical failure have been reported to predict SRLs response, including intensity in T2 weighted MRI, short acute octreotide test (sAOT), and different molecules such as SST2 and E-cadhe...

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Endocrine Abstracts

Acrostart: Spanish retrospective study to determine the timeframe to achieve hormonal normalisation with initial Somatuline Autogel^® treatment in acromegaly patients in routine clinical practice

Precision medicine in acromegaly: results of the ACROFAST study

BiosciAbstracts

Endocrine Abstracts

Acrostart: Spanish retrospective study to determine the timeframe to achieve hormonal normalisation with initial Somatuline Autogel® treatment in acromegaly patients in routine clinical practice

Precision medicine in acromegaly: results of the ACROFAST study

BiosciAbstracts

Acrostart: Spanish retrospective study to determine the timeframe to achieve hormonal normalisation with initial Somatuline Autogel^® treatment in acromegaly patients in routine clinical practice